An Evaluation of Immobilized Poly-(S)-N-(1-phenylethyl)acrylamide Chiral Stationary Phases

In this study, brush type and polymer stationary phases were prepared based on (S)-N-(1-phenylethyl) acrylamide, the polymeric phase demonstrated superior chiral recognition ability. The two synthesized by strategies, one was “grafting from” method, which obtained CSP initiating monomer polymerization surface of 3-methacrylatepropyl silica gel, other to”, fixed copolymer acrylamide trimethoxysilylpropyl methacrylate gel. A comparison these bonding modes revealed that produced to” had higher Further improvement can be achieved end-capping silanol groups with trimethylchlorosilane to reduce non-enantioselective retention caused residual improve peak shape enantiomers. Chiral separation in subcritical fluid chromatography also studied. Similar enantioselectivity results resolution observed due shape.